These inflammatory words of criticism and condemnation fanned the smoldering embers of Pharisaic hostility into an inferno of hatred and hostility. Luke wrote that these religious leaders now questioned Him closely on many subjects. He had challenged their expertise. Now they sought to defend themselves by discrediting Him. They plotted against Him seeking to trip Him up and trap Him. They also tried to get Him to say something wrong, unwise, or inappropriate. This antagonism escalated shortly after the encounter that Luke just described ( Luke 11:53). These verses document the Jewish religious leaders" official rejection of Jesus (cf. Matthew 12; Mark 12). [source][source][source]
Luke"s original readers would have learned the importance of accepting and believing Jesus" teachings as a result of Luke"s selection of material in this section ( Luke 11:14-54). To fail to do so results in dire consequences. Listening to the Word of God continues to be a major emphasis in this section. Furthermore the hypocrisy that characterized the Pharisees and scribes can also mark disciples of Jesus if we elevate ritual observance above real worship. Jesus developed this idea in the next pericope ( Luke 12:1-12). [source][source][source]
"The issues Jesus raises here [1] are dangers that those of a conservative theological bent always face. In pursuit of truth and the way of God, far too many people conduct their zeal for righteousness by making sure that every "i" is dotted and every "t" crossed, and by watching over others to make sure they are acting properly. On the other hand, these same people have often lost sensitivity to God"s call for justice. God wants us to care about those whose plight is less fortunate than our own ( Romans 12:16)." [2][source]